Human Adipose Stem Cells: Current Clinical Applications (Summary)

Adipose-derived stem cells are multipotent cells that can easily be
extracted from adipose tissue, are capable of expansion in vitro, and have the
capacity to differentiate into multiple cell lineages, which have the potential for
use in regenerative medicine. However, several issues need to be studied to
determinesafehumanuse.Forexample,therearequestionsrelatedtoisolation
andpurificationofadipose-derivedstemcells,theireffectontumorgrowth,and
the enforcement of U.S. Food and Drug Administration regulations. Numerous
studies have been published, with the interest in the potential for regenerative
medicine continually growing. Several clinical trials using human adipose stem
cell therapy are currently being performed around the world, and there has
been a rapid evolution and expansion of their number. The purpose of this
article was to review the current published basic science evidence and ongoing
clinic altrialsinvolvingtheuse of adipose-derived stem cells in plastic surgery and
in regenerative medicine in general. The results of the studies and clinical trials
using adipose-derived stem cells reported in this review seem to be promising Imagenot
only in plastic surgery but also in a wide variety of other specialties. Nevertheless,
those reported showed disparity in the way adipose-derived stem cells were used.
Further basic science experimental studies with standardized protocols and larger
randomized trials need to be performed to ensure safety and efficacy of adipose derived
stem cells use in accordance with U.S. Food and Drug Administration
guidelines.

Source:

Phanette Gir, M.D.
Georgette Oni, M.D.
Spencer A. Brown, Ph.D.
Ali Mojallal, M.D., Ph.D.
Rod J. Rohrich, M.D.

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