Avascular necrosis also known as osteonecrosis, aseptic necrosis, and ischemic bone necrosis. It is a disease resulting from the temporary or permanent loss of the blood supply to the bones. Without blood, the bone tissue dies and causes the bone to collapse.
Mesenchymal stem cells (MSC) from adult bone marrow are multipotent that can differentiate into fibroblastic, osteogenic, myogenic, adipogenic and reticular cells providing a potential therapy for bone repair.
Stem cell transplantation into the core decompression site replaces dead area by the differentiation process of stem cells into the bone cells as well as improves intramedullary vascularity. Along with MRI evidence, the measured physical therapy outcomes, subjective pain, and functional status all improved.