Ulcerative Colitis Treatment Protocol at StemRx Mumbai

Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms of abdominal pain, diarrhea, and rectal bleeding.

Ulcerative colitis is closely related to another condition of inflammation of the intestines called Crohn’s disease. Together, they are frequently referred to as inflammatory bowel disease (IBD).

Ulcerative colitis likely involves abnormal activation of the immune system in the intestines. The immune system is composed of immune cells and the proteins that these cells produce. These cells and proteins serve to defend the body against harmful bacteria, viruses, fungi, and other foreign invaders. Activation of the immune system causes inflammation within the tissues where the activation occurs. (Inflammation is, in fact, an important mechanism of defense used by the immune system.) Normally, the immune system is activated only when the body is exposed to harmful invaders. In patients of ulcerative colitis, however, the immune system is abnormally and chronically activated in the absence of any known invader. The continued abnormal activation of the immune systems causes chronic inflammation and ulceration. The susceptibility to abnormal activation of the immune system is genetically inherited. First degree relatives (brothers, sisters, children, and parents) of patients with IBD are thus more likely to develop these diseases.

Ulcerative colitis facts

    • Ulcerative colitis is an inflammation of the large intestine (colon).
    • The cause of ulcerative colitis is unknown.
    • Intermittent rectal bleeding, crimpy abdominal pain and diarrhea often are symptoms of ulcerative colitis.
    • The diagnosis of ulcerative colitis can be made with a barium enema, but direct visualization (sigmoidoscopy or colonoscopy) is the most accurate means of diagnosis.
    • Long-standing ulcerative colitis is a risk factor for colon cancer.
    • Treatment of ulcerative colitis may involve both medications and surgery.
    • Ulcerative colitis also can cause inflammation in joints, spine, skin, eyes, and the liver and its bile ducts.

The Autologous Stem Cell Transplant is a new technique that restores tissue function in patients with severe damage in different body organs. In general terms, the treatment consists of hematopoietic stem cell collection from the patient’s own body; concentration, preservation and infusion of those cells in the patient’s affected organs and body areas. The stem cells are harvested from the bone marrow or peripheral blood of the patient.
Stem cells and specifically, mesenchymal stem cells with their immunoregulatory characteristics, differentiation capacity and trophic potential home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient’s whole body. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.

Advertisements

StemRx: Carry your Repair Kit with Yourself

You may surprise after reading the title but it is true that you carry your repair kit with yourself naturally.  i.e. your stem cells. Stem cells are biological cells found in all multicellular organisms that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce more stem cells.

Stem cells are the most promising tools in combating genetic disorders and human diseases such as diabetes, cancer, Parkinson’s disease, heart disease, etc., which are difficult to treat by conventional therapeutic methods. Even though all kinds of stem cells have potential uses, the embryonic type is easier to extract and believe to have more advantages as compared to the adult stem cells and induced stem cells.
There are three accessible sources of autologous adult stem cells in humans:
·         Bone marrow
·         Adipose tissue (lipid cells)
·         Blood
Most stem cells are in your bone marrow. You also have some in your blood that circulate from your bone marrow. Bone marrow stem cells turn into red blood cells, white blood cells, or platelets to help your body stay healthy.
At StemRx team of stem cell researchers will treat your disease or injuries with autologous stem cells therapy. Autologous cell therapies are emerging therapeutic intervention where it introduces or uses cells or tissues from your blood, then cultured, expanded and re-introduced at the site of the your disease. They are widely promoted as next pillar or advancement in medical care.
Let me explain by an example.  If your bone marrow is attacked by a disease such as multiple myeloma, it can no longer make normal blood cells. In a stem cell transplant, healthy stem cells are placed in your body through an IV (Intravenous) to help your bone marrow start to work right.
When the stem cells come from your own blood or bone marrow, it is called an autologous transplant. StemRx have treated hundreds of patients through its internationally accepted autologous stem cells treatments.
For More info visit www.stemrx.in

Treatment Protocol for Osteoarthritis followed at StemRx

At stemRx we have developed and following the Treatment Protocol for Osteoarthritis. It is briefly explained below.

Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types,including: osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells).

Mesenchymal stem cells (MSCs) are adult autologous stem cells found in the bone marrow. However, mesenchymal stem cells can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube, and fetal liver and lung. Mesenchymal stem cells are a distinct entity to the mesenchyme, embryonic connective tissue which is derived from the mesoderm and differentiates to form hematopoietic stem cells.Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to regenerate bone.

Current treatment for cartilage damage in osteoarthritis focuses on surgical interventions such as arthroscopic debridement, microfracture, and cartilage grafting/transplant, total joint replacement. These procedures have complications than hoped, are invasive, and often entail a prolonged recovery time. MSCs can be harvested from the iliac crest through Bone Marrow Aspiration, expanded using the patient’s own growth factors from platelet lysate, then successfully implanted to increase cartilage volume in an adult human knee.

We present a review highlighting the developments in cellular and regenerative medicine in the arena mesenchymal stem cell therapy by successful harvest, expansion, and transplant of autologous mesenchymal stem cells into an adult human knee that repairs the cartilage, ligaments & meniscal damage & lubricate the joint space.

For More information on Osteoarthritis treatment using stem cells visit http://www.stemrx.in