Ankylosing Spondylitis : Evidence of improvement with stem cell Treatment | Recent case study

Patient’s Treatment Timeline :

16.07.2013

A 39 years male patient was admitted our hospital for treatment of Ankylosing Spondylitis diagnosed 6 years back; with C/O Pain in Hip Joint & back increased since 6 months, occasional knee pain & numbness in all extremities.

Physical Examination: Stiffness and restricted movements in cervical & lumbar spine.

Pathological Findings: ANA & HLAB27 Positive

The Plan of Treatment:

  1. Autologus Mesenchymal Stem Cell Transplant with Stromal factor

Bone Marrow & Adipose Tissue derived Mecenchymal Stem Cells with Stromal factor was transplanted through intravenous transplant.

As the Ankylosing Spondylitis is a auto immune disorder in which inflammation causes tissue damage, Stem Cell transplant helps by immunomodulatory & anti inflammatory action.

  1. Supplementation of deficient vitamins like D3, B12 and minerals like zinc, calcium; amino acids like glutathyon, argenine and proteins so as to maintain the micro environment needed for stem cell to differentiate and maintain the potency.
  2. Physiotherapy exercise & Acupuncture Therapy as per Chinese Traditional Method

Diet

The patient is recovering well with 40 % increased mobility and flexibility without pain.  The confidence level is increased.

Further two sessions of transplant is planned in next six months.

Stem Cell Treatment Procedure

Step 1

Patient Evaluation + Diagnostic Investigations

Step 2

Aspiration of Stem Cells from Bone Marrow and Adipose Tissues

Step 3

Processing of Stem Cells in Tissue Culture Laboratory

Step 4

Transplantation of stem cells

Step 5

Application of Allied Therapies

Stem Cell Treatment have shown wonderful improvements in Ankylosing Spondylitis. This treatment is available at our all centers in Mumbai and Benglore. After this treatment almost all our AS patients are now is good condition and enjoying there life to fullest.

 

 

Ulcerative Colitis Treatment Protocol at StemRx Mumbai

Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms of abdominal pain, diarrhea, and rectal bleeding.

Ulcerative colitis is closely related to another condition of inflammation of the intestines called Crohn’s disease. Together, they are frequently referred to as inflammatory bowel disease (IBD).

Ulcerative colitis likely involves abnormal activation of the immune system in the intestines. The immune system is composed of immune cells and the proteins that these cells produce. These cells and proteins serve to defend the body against harmful bacteria, viruses, fungi, and other foreign invaders. Activation of the immune system causes inflammation within the tissues where the activation occurs. (Inflammation is, in fact, an important mechanism of defense used by the immune system.) Normally, the immune system is activated only when the body is exposed to harmful invaders. In patients of ulcerative colitis, however, the immune system is abnormally and chronically activated in the absence of any known invader. The continued abnormal activation of the immune systems causes chronic inflammation and ulceration. The susceptibility to abnormal activation of the immune system is genetically inherited. First degree relatives (brothers, sisters, children, and parents) of patients with IBD are thus more likely to develop these diseases.

Ulcerative colitis facts

    • Ulcerative colitis is an inflammation of the large intestine (colon).
    • The cause of ulcerative colitis is unknown.
    • Intermittent rectal bleeding, crimpy abdominal pain and diarrhea often are symptoms of ulcerative colitis.
    • The diagnosis of ulcerative colitis can be made with a barium enema, but direct visualization (sigmoidoscopy or colonoscopy) is the most accurate means of diagnosis.
    • Long-standing ulcerative colitis is a risk factor for colon cancer.
    • Treatment of ulcerative colitis may involve both medications and surgery.
    • Ulcerative colitis also can cause inflammation in joints, spine, skin, eyes, and the liver and its bile ducts.

The Autologous Stem Cell Transplant is a new technique that restores tissue function in patients with severe damage in different body organs. In general terms, the treatment consists of hematopoietic stem cell collection from the patient’s own body; concentration, preservation and infusion of those cells in the patient’s affected organs and body areas. The stem cells are harvested from the bone marrow or peripheral blood of the patient.
Stem cells and specifically, mesenchymal stem cells with their immunoregulatory characteristics, differentiation capacity and trophic potential home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient’s whole body. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.

StemRx: Carry your Repair Kit with Yourself

You may surprise after reading the title but it is true that you carry your repair kit with yourself naturally.  i.e. your stem cells. Stem cells are biological cells found in all multicellular organisms that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce more stem cells.

Stem cells are the most promising tools in combating genetic disorders and human diseases such as diabetes, cancer, Parkinson’s disease, heart disease, etc., which are difficult to treat by conventional therapeutic methods. Even though all kinds of stem cells have potential uses, the embryonic type is easier to extract and believe to have more advantages as compared to the adult stem cells and induced stem cells.
There are three accessible sources of autologous adult stem cells in humans:
·         Bone marrow
·         Adipose tissue (lipid cells)
·         Blood
Most stem cells are in your bone marrow. You also have some in your blood that circulate from your bone marrow. Bone marrow stem cells turn into red blood cells, white blood cells, or platelets to help your body stay healthy.
At StemRx team of stem cell researchers will treat your disease or injuries with autologous stem cells therapy. Autologous cell therapies are emerging therapeutic intervention where it introduces or uses cells or tissues from your blood, then cultured, expanded and re-introduced at the site of the your disease. They are widely promoted as next pillar or advancement in medical care.
Let me explain by an example.  If your bone marrow is attacked by a disease such as multiple myeloma, it can no longer make normal blood cells. In a stem cell transplant, healthy stem cells are placed in your body through an IV (Intravenous) to help your bone marrow start to work right.
When the stem cells come from your own blood or bone marrow, it is called an autologous transplant. StemRx have treated hundreds of patients through its internationally accepted autologous stem cells treatments.
For More info visit www.stemrx.in

Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome.

Transplantation of mesenchymal stem cells (MSCs) derived from bone marrow has been shown to improve functional outcome in spinal cord injury (SCI). Systemic and intrathecal delivery of MSCs results in therapeutic benefits in a number of experimental central nervous system disorders.

In the present study we transplanted MSCs derived from bone marrow through Lumbar Puncture at various time intervals after transplantation of a severe contusive SCI to study their therapeutic effects. MSCs were systemically delivered at varied time intervals (6h to 28 days after SCI).

The availability of autologous MSCs in large number and the potential for systemically delivering cells to target lesion areas without neurosurgical intervention suggests the potential utility of intravenous cell delivery as a prospective therapeutic approach in acute and subacute SCI.