Stem Cells Therapy for Better Quality Life Not For Controversies…!

The much publicized stem cell research debate focusing on moral arguments is off target with the goal of real progress in the quality of human life and other therapeutic benefits potential. Stem cells are a valuable renewing asset of human body and thus are deserving of our intense interest, but passionate disagreement about research and cloning issues miss the mark of discovering just how simply we can use what we already know about stem cells and how we can benefit from that knowledge to improve the health of everyone.

Let us now discuss different types of sources of stem cells. These include allogenic, xenogenic and autologous. Allogenic is the type in which cells come from a donor of same species. As these do not have any standard surface of cells markers triggering immune response, they can be used without the fear of being rejected by the tissues of the host. xenogenic cells are taken from the donor of another species. Hence there are chances of these cells being rejected but due to some particular characteristics they may survive in the body in which they would be injected. As far as the autologous type is concerned, it is considered to be the best type as these come from the same species and hence there are no chances of rejection of these. Moreover these cells also narrowly escape most competitively from immune system.   

These are targeted into the body in areas where there is some kind of injury. Basic purpose of transplanting these stem cells is to target the injury. These are responsible for some part of the tissues which are newly formed. Rest of the repair is done by residential stem cells present in the body. If large number of cells will be injected, and then it enhances the healing under ideal conditions, it would respond and healing would take place.
Recent medical technology has provided stem-cell replacement programs that cost less than all other medical and surgical therapies presently available. These affordable bio cellular alternatives may be crucial for sufferers of Parkinson’s disease, some types of diabetes, cerebral palsy, orthopedic conditions, spinal cord injuries, kidney problems, ischemic heart disease and many other conditions.

This scenario might sound like pure science fiction, but it could become reality a few decades from now. Stem cells have attracted huge scientific and public interest, not only because they bear the promise of miracle cures for age-related heart diseases, but also because their medical use is so appealing: stem-cell therapy could augment the human body’s own regenerative capacity, which declines as we grow older. The appropriate source of cells for these therapeutic applications is hotly debated, but the technical feasibility of generating replacement tissues and organs is well within realistic projections. Nevertheless, although the prospect of rejuvenation has captured the public imagination, the field is plagued with controversy: some of the most dramatic studies have been subsequently refuted, and heated ethical debates threaten to distort the scientific work that must be done before stem-cell therapy can become a medical reality.

It is all thanks to this new and developed process that people can see amazing things going around them. 


Syndrome of Early Post Transplantation Improvement

We call this as syndrome of collective signs & symptoms, patient suffer due to ageing & degeneration in general than the primary complaints for which he is given treatment.

MSCs actively interfere with immune tolerance. Mesenchymal Stem cells (MSCs) are known for their properties of

  1. Immunomodulation,
  2. Anti-apoptosis
  3. Angiogenesis
  4. Anti-scarring,
  5. Homing through chemo-attraction
  6. Improving inter cellular electrical signal transduction
  7. Support  growth & differentiation of patient’s own stem and progenitor cells.

The first stage lasts for about one month and is characterized by emergence of early clinical symptoms that develop within a few hours after transplantation stem cells. We have described the early post-transplantation improvement syndrome: improvement in overall health and appetite, diminishing weakness and sweating, restoration of self-care ability, reduction of somatic depression, improvement of emotional status, cognitive abilities, memory and increase in performance, vigor & vitality.

The second stage of cell effect begins within one to two months after transplantation. It is related to reduced clinical manifestations of the disease and is characterized by stabilisation of haemopoesis, improvement of the immunological profile, reduction of inflammatory effects, elevation of Karnofsky index, and improved quality of life.

The improvement is seen as follows—

  • In 65%  cases restoration of work capacity, appetite & sleep is seen.
  • In 50% cases improvement in thinking & mental capacity, disappearance of anxiety, depression, re-vitalization is seen.
  • In 60% cases restoration of immunological parameters is seen.
  • In 80% cases restoration of hematopoiesis, normalization of erythrocyte count & hemoglobin is seen.
  • In 70% cases microcirculation improves, trophic ulcers disappear as well as infectious skin lesions, fungus dermatitis, cutaneus lychenisation & lipoatrophic lesions decrease.

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Treatment Protocol for Osteoarthritis followed at StemRx

At stemRx we have developed and following the Treatment Protocol for Osteoarthritis. It is briefly explained below.

Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types,including: osteoblasts (bone cells), chondrocytes (cartilage cells), and adipocytes (fat cells).

Mesenchymal stem cells (MSCs) are adult autologous stem cells found in the bone marrow. However, mesenchymal stem cells can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube, and fetal liver and lung. Mesenchymal stem cells are a distinct entity to the mesenchyme, embryonic connective tissue which is derived from the mesoderm and differentiates to form hematopoietic stem cells.Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to regenerate bone.

Current treatment for cartilage damage in osteoarthritis focuses on surgical interventions such as arthroscopic debridement, microfracture, and cartilage grafting/transplant, total joint replacement. These procedures have complications than hoped, are invasive, and often entail a prolonged recovery time. MSCs can be harvested from the iliac crest through Bone Marrow Aspiration, expanded using the patient’s own growth factors from platelet lysate, then successfully implanted to increase cartilage volume in an adult human knee.

We present a review highlighting the developments in cellular and regenerative medicine in the arena mesenchymal stem cell therapy by successful harvest, expansion, and transplant of autologous mesenchymal stem cells into an adult human knee that repairs the cartilage, ligaments & meniscal damage & lubricate the joint space.

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