Multiple sclerosis Can be cured with stem cells therapy in india

Multiple sclerosis is an immunological disorder, which causes inflammation of brain, more common in females than males. It is the disseminated disease of central nervous system in which there is a loss of communication between the organs. The insulating covers of nerve cells called as myelin sheath, which send electrical signals in brain and spinal cord, are deteriorated. The cause for multiple sclerosis is not yet known but abnormal response by immune system damages the myelin sheath. The other causes for MS are immunological, environmental, genetic and infectious. The gene associated with MS is HLA-DRB1 which plays an important role in immune recognition.  It is generally considered to be an auto-immune disease, and other factors that may be responsible are genetics or childhood infection.

The Four Courses of MS are:

  • Relapsing-Remitting MS: People with this type of MS have defined attacks like relapses and flare-ups and there is no disease progression during this interval.
  • Primary-progressive MS: This type of MS shows worsening of neurological function with no remissions and relapses.
  • Secondary-progressive MS: At this stage disease worsens more steadily with or without occasional; flare-ups, relapses-remissions.
  • Progressive-relapsing MS: At this stage MS patients experience worsening of neurological function in long way without any further remissions and no recovery.

Signs and Symptoms:

  • Blurred vision
  • Tingling and numbness
  • Pain and muscle spasm
  • Fatigue, weakness and dizziness
  • Hearing loss
  • Slurred speech
  • Memory loss
  • Breathing problem

The signs and symptoms mentioned above are not exactly the same for all the patients suffering from MS.

Image

Diagnosis of MS is based on proper medical history, neurological examination, MRI, spinal taps, lumbar punctures, asking right questions to the patients. The most commonly used MS drugs are teriflunomide, interferon, Betaseron, Copaxone, Gilenya and Novantrone.

Stem cells are renewing cells that have ability to differentiate in new cells. Stem cell therapy helps in increasing the blood circulation, myelin regeneration, mitochondrial energy production and dietary, anti-inflammatory, antimicrobial and antioxidant factors. Stem cells are classified as Adult stem cells and embryonic stem cells, which are further classified according to the way they are derived and sources tissues like, Mesenchymal stem cells(MSC’s), Hematopoietic stem cells(HSC’s) and induced pluripotent stem cells(iPS)cells are the major types of stem cells.

Autologous stem cells are derived from patient’s own body and can be obtained from bone marrow, adipose tissue and Peripheral blood. We use Mesenchymal stem cells derived from bone marrow, adipose tissue, which are self renewing cells derived from adult tissues that can from a number of cells or tissues that are usually restricted to a particular germ layer.Mesenchymal stem cell has immune regulatory properties that help regeneration of myelin sheath of affected neurons.

The major advantage of using MSC’s is the ease of harvest and lack of immunoreactivity since they are derived from autologous sources.

These are then processed in tissue culture lab to isolate stem cells which are then used for the therapeutic purposes and are then given epidurally, intrathecally, intradiscally or intravenously depending on the type of disease.

Post stem cell treatment includes team of members that consists of nurse, a psychiatrist, physical therapist, and nutritionist, and dietitian, urologist followed by yoga, exercise, and acupuncture.

Image

Ultimate & Advanced treatment for Multiple Sclerosis

Multiple Sclerosis (Disseminated sclerosis or Encephalomyelitis disseminata).

Multiple sclerosis is an inflammatory, autoimmune disease of central nervous system. It destroys myelin, oligodendrocytes and axons affecting the brain and spinal cord. This results in loss of muscle control, vision, balance and sensation. It occurs in both males and females in a ratio of 1:3. A person is high at risk of developing this disease from 13 to 50years of age, which gradually declines thereafter.

Causes of Multiple sclerosis range from genetic mutations, environmental factor and viral infection. The symptoms start between the age of 20 and 40 with a trend of gradual improvement, but may relapse. Early symptoms of MS include blurred or double vision, thinking problems, weakness in arms or legs. The common symptoms are abnormal sensations, bladder problems, fatigue, sexual difficulties, tremors, speech problems, muscle spasms and very rare cases reported breathing problems and seizures.

There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks. Diagnosis of MS is based on ones medical history, Neurological examination, MRI, spinal taps, lumbar punctures.

Conventional methods followed to treat MS:

  • The use of the cannabis-derived drug Sativex.
  • Low Dose Naltrexone.
  • Massage.
  • Yoga.
  • Acupuncture.

 

Medications used to treat MS while modestly effective can have adverse effects and be poorly tolerated.

 

Stem Cell Treatment harnesses:

Immunomodulators-

  • Aubagio (teriflunomide).
  • Avonex (interferon).
  • Betaseron (interferon beta-1b).
  • Copaxone (glatiramer acetate).
  • Gilenya (fingolimod).
  • Novantrone (mitoxantrone).

 

Immunosuppressants-

  • Solu-Medrol.
  • Corticosteroids.
  • mitoxantrone (Novatrone).
  • Methotrexate.
  • mitoxantrone (Cytoxin).

Medications used to treat MS while modestly effective can have adverse effects and be poorly tolerated.

Clinical Course:

  • Relapsing remitting.
  • Secondary progressive.
  • Primary progressive.
  • Progressive relapsing.

 

An Operational team for treatment include:

  • Psychiatrist
  • Physiotherapist
  • Occupational therapist
  • Nutritionist,
  • Urologist,
  • Speech therapist.

Stem cell Therapy for MS:

Present stem cell therapy for MS includes immune-modulation or immunosuppressant along with novel approaches such as interferon, capaxone, or immune suppressants. All act in a non-specific manner blocking immune responses against myelin sheath. Mesenchymal stem cells have immune-regulatory properties that help in regeneration of myelin sheaths of affected neurons. Mesenchymal stem cells and T regulatory cells are embedded inside this tissue. Infusion of adult neural stem cell showed a significant reduction in axonal lesions in multiple locations. Several factors like Brain derived neutrophic factor and Neutrophic-3. Fyn tyrosine kinase is an additional factor that can increase the production of myelin base protein production for remyelination of axons.

Stem cell therapy helps to increase the blood circulation, myelin regeneration, mitochondrial energy production, dietary changes, anti-inflammatory, and antimicrobial and antioxidant factors.