Ulcerative Colitis Treatment Protocol at StemRx Mumbai

Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms of abdominal pain, diarrhea, and rectal bleeding.

Ulcerative colitis is closely related to another condition of inflammation of the intestines called Crohn’s disease. Together, they are frequently referred to as inflammatory bowel disease (IBD).

Ulcerative colitis likely involves abnormal activation of the immune system in the intestines. The immune system is composed of immune cells and the proteins that these cells produce. These cells and proteins serve to defend the body against harmful bacteria, viruses, fungi, and other foreign invaders. Activation of the immune system causes inflammation within the tissues where the activation occurs. (Inflammation is, in fact, an important mechanism of defense used by the immune system.) Normally, the immune system is activated only when the body is exposed to harmful invaders. In patients of ulcerative colitis, however, the immune system is abnormally and chronically activated in the absence of any known invader. The continued abnormal activation of the immune systems causes chronic inflammation and ulceration. The susceptibility to abnormal activation of the immune system is genetically inherited. First degree relatives (brothers, sisters, children, and parents) of patients with IBD are thus more likely to develop these diseases.

Ulcerative colitis facts

    • Ulcerative colitis is an inflammation of the large intestine (colon).
    • The cause of ulcerative colitis is unknown.
    • Intermittent rectal bleeding, crimpy abdominal pain and diarrhea often are symptoms of ulcerative colitis.
    • The diagnosis of ulcerative colitis can be made with a barium enema, but direct visualization (sigmoidoscopy or colonoscopy) is the most accurate means of diagnosis.
    • Long-standing ulcerative colitis is a risk factor for colon cancer.
    • Treatment of ulcerative colitis may involve both medications and surgery.
    • Ulcerative colitis also can cause inflammation in joints, spine, skin, eyes, and the liver and its bile ducts.

The Autologous Stem Cell Transplant is a new technique that restores tissue function in patients with severe damage in different body organs. In general terms, the treatment consists of hematopoietic stem cell collection from the patient’s own body; concentration, preservation and infusion of those cells in the patient’s affected organs and body areas. The stem cells are harvested from the bone marrow or peripheral blood of the patient.
Stem cells and specifically, mesenchymal stem cells with their immunoregulatory characteristics, differentiation capacity and trophic potential home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient’s whole body. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.

Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome.

Transplantation of mesenchymal stem cells (MSCs) derived from bone marrow has been shown to improve functional outcome in spinal cord injury (SCI). Systemic and intrathecal delivery of MSCs results in therapeutic benefits in a number of experimental central nervous system disorders.

In the present study we transplanted MSCs derived from bone marrow through Lumbar Puncture at various time intervals after transplantation of a severe contusive SCI to study their therapeutic effects. MSCs were systemically delivered at varied time intervals (6h to 28 days after SCI).

The availability of autologous MSCs in large number and the potential for systemically delivering cells to target lesion areas without neurosurgical intervention suggests the potential utility of intravenous cell delivery as a prospective therapeutic approach in acute and subacute SCI.

StemRx Bio Science Solutions: Treat yourself with your Stem Cells

The outcomes of using human stem cells are huge. Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Stem cells are distinctive from any other adult cell of the body in that they are capable of continuous mitotic divisions and self-renewal over long periods without undergoing the process of differentiation.

Biological cells found in all multicellular organisms, that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce more stem cells. Stem cells can be found throughout the body after embryonic development. Using those stem cells could greatly help in curing diseases or help create new medicine. For example, it could be completely possible to create viable and healthy heart muscle cells in laboratory and then transplant those healthy cells into a patient with heart disease. Obviously, those cells would have to come from that same patient to prevent any risk of the new cells being rejected by the body of the patient.

Private stem cells bank are slightly different though as the cord blood or stem cells collected are not supposed to be used for research purposes. They are used by new parents who want to safeguard their baby or babies’ future by getting the cord blood or simply the stem cells in a specialized bank in case they get a something like leukaemia or a cancer and need stem cells to treat them. Another example is that cells taken from a person could be used to test new medicine on them for safety, to make sure they are absolutely safe to use.

StemRx Bio Science Solutions provides several stem cells treatments. At StemRx Bio Science Solutions the tissue culture laboratory is designed most professionally and to maintain total contamination free atmosphere by using class 10000 HEPA filters. The therapy is given in the most ultra modern operation theatre having all the facilities from multi Para monitor, ventilation system to image intense fire facility and operative microscope.

StemRx Bio Science Solutions boast the team of highly experienced and most qualified doctors and biology researchers for the developments of new therapies of stem cells.At StemRx Bio Science Solutions we use autologous stem cells derived from bone marrow, adipose tissue or peripheral blood supported and activated by specific growth factors and platelets (PRP). Ailments successfully treated at our centre are

  • Osteoarthritis
  • Diabetes Mellitus
  • Tendinitis
  • Spinal Injuries
  • Avascular Necrosis
  • Frozen Shoulder
  • Non healing Diabetic wound
  • Hair  Therapy

The researches on stem cells bring hope of new ways to treat disease, it is important to store those cells. And the best source of stem cells to treat you is your stem cells. StemRx Bio Science Solutions is right place to get treated and live healthy with help of your stem cells. Though it is difficult to understand and looks like critical but you can call it a miracle of science and for sure with anyone miracles can happen.