Transplantation of mesenchymal stem cells (MSCs) derived from bone marrow has been shown to improve functional outcome in spinal cord injury (SCI). Systemic and intrathecal delivery of MSCs results in therapeutic benefits in a number of experimental central nervous system disorders.
In the present study we transplanted MSCs derived from bone marrow through Lumbar Puncture at various time intervals after transplantation of a severe contusive SCI to study their therapeutic effects. MSCs were systemically delivered at varied time intervals (6h to 28 days after SCI).
The availability of autologous MSCs in large number and the potential for systemically delivering cells to target lesion areas without neurosurgical intervention suggests the potential utility of intravenous cell delivery as a prospective therapeutic approach in acute and subacute SCI.