recently i presented this lecture for cme at D Y Patil Intitute of Life Sciences at Navi Mumbai
Hip surgeries are usually traumatic and followed by weeks and months of discomfort while attempting to redevelop strength and mobility. In this situation, one could opt for stem cell therapy. It is known as one of the most effective alternative of hip replacement surgery.
What is Cellular Treatment?
Stem cell therapy refers to body’s own ability to cure itself with the help of autologous cells. These cells are unique as they combine two unique properties which are Pluripotency and self-renewal. Pluripotency means they can give rise to multiple cell types. Plus, they have the ability to divide and self-renew to maintain the original population of cells. These pluripotent cells multiply themselves indistinctly when comes in contact with diseased organ and give rise to new healthy cells that replace diseased cells in an organ. Owing to this unique property, cells are treating and curing various chronic diseases by repairing the affected area or organ of the human body.
What are the advantages of Stem Cell Therapy?
Like in any other part of the world stem cells are used and investigated in our country as researchers aim to accomplish the possibility of curing any disease with the help of stem cells. They simply produce new healthy cells from the patient or from a healthy person and transplant them in the human body to cure the disease.
• This treatment deals with almost the complete human body, thus any disease can find treatment or complete cure.
• This method of extracting stem cells from the bone marrow is cost effective compared to conventional treatment in many conditions.
• Cellular Treatments have the ability to save lives – with therapy it has been proven that a healthier and longer life can be achieved.
• Regenerative medicine can cure blindness, hair loss, and are effective in anti-aging as well.
The cost of this regenerative therapy in India is lower compared to most part of the world. This innovative and traditional therapy of curing excruciating hip joint pains has been around for years yet many are now discovering its benefits. However, it is imperative to gain ample amount of knowledge on this treatments method in order to make most out of it. There are reliable healthcare centres available that can provide complete solution to patients with stem cell therapy. So its time to say good bye to chronic pains with hassle free stem cell therapy. This non-surgical method of treating pain is the ideal solution against hip replacement surgery.
You can get more information about stem cell therapies available in India athttp://www.stemrx.in
It is true that you carry your repair kit with yourself naturally. i.e. your stem cells. Stem cells are biological cells found in all multicellular organisms that can divide (through mitosis) and differentiate into diverse specialized cell types and can self-renew to produce morecells.
Stem cell information is very significant to us in order to dig deeper and fathom the issues associating stem therapy. Human body is made up of cells that function to different parts of the body. Cells are microscopic matters, their performance inside is a big factor on how our body in general performs. They are like human too; they have life stages, life span and susceptible to infections. Cells act like a driver and human is the vehicle; when they are sick they might bump the vehicle and as a human we will set sick as well.
Stem cells help the formation of human inside the womb from a simple zygote to fetus. What differ stems from the other are they are young, active group of cells and capable to replicate in an enormous level. They are present to all living organisms with cellular structure. Here we can imagine what significant roles stems are playing to our body. They are used in the latest medical remedy provided at StemRx which is the stem cells treatments.
Stem cell research can potentially help treat a range of medical problems. It could lead humanity closer to better treatment and possibly cure a number of diseases:
- Heart Diseases, Stroke and Diabetes (Type 1)
- Birth Defects
- Spinal Cord Injuries
- Replace or Repair Damaged Organs
- Haematopoiesis (blood cell formation)
- Reduced Risk of Transplantation (You could possibly get a copy of your own heart in a heart-transplantation in the future)
- Wound Healing
- Parkinson’s Disease
- Alzheimer’s Disease
- Missing teeth
- Blindness and vision impairment
Better treatment of these diseases could also give significant social benefits for individuals and economic gains for society. StemRx strives to make your life better with the stem cells treatments.
The researches on these cells bring hope of new ways to treat disease, it is important to store those cells. And the best source of stem cells to treat you is your stem cells. StemRx Bio Science Solutions is right place to get treated and live healthy with help of your cells. Though it is difficult to understand and looks like critical but you can call it a miracle of science and for sure with anyone miracles can happen.
Multiple sclerosis is an immunological disorder, which causes inflammation of brain, more common in females than males. It is the disseminated disease of central nervous system in which there is a loss of communication between the organs. The insulating covers of nerve cells called as myelin sheath, which send electrical signals in brain and spinal cord, are deteriorated. The cause for multiple sclerosis is not yet known but abnormal response by immune system damages the myelin sheath. The other causes for MS are immunological, environmental, genetic and infectious. The gene associated with MS is HLA-DRB1 which plays an important role in immune recognition. It is generally considered to be an auto-immune disease, and other factors that may be responsible are genetics or childhood infection.
The Four Courses of MS are:
- Relapsing-Remitting MS: People with this type of MS have defined attacks like relapses and flare-ups and there is no disease progression during this interval.
- Primary-progressive MS: This type of MS shows worsening of neurological function with no remissions and relapses.
- Secondary-progressive MS: At this stage disease worsens more steadily with or without occasional; flare-ups, relapses-remissions.
- Progressive-relapsing MS: At this stage MS patients experience worsening of neurological function in long way without any further remissions and no recovery.
Signs and Symptoms:
- Blurred vision
- Tingling and numbness
- Pain and muscle spasm
- Fatigue, weakness and dizziness
- Hearing loss
- Slurred speech
- Memory loss
- Breathing problem
The signs and symptoms mentioned above are not exactly the same for all the patients suffering from MS.
Diagnosis of MS is based on proper medical history, neurological examination, MRI, spinal taps, lumbar punctures, asking right questions to the patients. The most commonly used MS drugs are teriflunomide, interferon, Betaseron, Copaxone, Gilenya and Novantrone.
Stem cells are renewing cells that have ability to differentiate in new cells. Stem cell therapy helps in increasing the blood circulation, myelin regeneration, mitochondrial energy production and dietary, anti-inflammatory, antimicrobial and antioxidant factors. Stem cells are classified as Adult stem cells and embryonic stem cells, which are further classified according to the way they are derived and sources tissues like, Mesenchymal stem cells(MSC’s), Hematopoietic stem cells(HSC’s) and induced pluripotent stem cells(iPS)cells are the major types of stem cells.
Autologous stem cells are derived from patient’s own body and can be obtained from bone marrow, adipose tissue and Peripheral blood. We use Mesenchymal stem cells derived from bone marrow, adipose tissue, which are self renewing cells derived from adult tissues that can from a number of cells or tissues that are usually restricted to a particular germ layer.Mesenchymal stem cell has immune regulatory properties that help regeneration of myelin sheath of affected neurons.
The major advantage of using MSC’s is the ease of harvest and lack of immunoreactivity since they are derived from autologous sources.
These are then processed in tissue culture lab to isolate stem cells which are then used for the therapeutic purposes and are then given epidurally, intrathecally, intradiscally or intravenously depending on the type of disease.
Post stem cell treatment includes team of members that consists of nurse, a psychiatrist, physical therapist, and nutritionist, and dietitian, urologist followed by yoga, exercise, and acupuncture.
Cerebral palsy with Dandy-Walker Syndrome
Cerebral means a portion of brain that is affected and palsy refers to complete or partial paralysis of muscles. Cerebral palsy is a hypernm that indicates abnormal activities of motor neurons which ceases the further brain development. It also affects the body tone and posture which is a result of brain lesions. Cerebral palsy is a disorder caused during pregnancy, delivery, or shortly after birth upto age3. Without sufficient oxygen and nutrients, brain cells are injured and killed. An ischemic blood circulation causes disruption in the energy producing mitochondria of the neurons.
Dandy Walker syndrome is a genetic sporadic condition that is present since birth and is a cause of increased cerebrospinal fluid in the brain.The condition is described by partial or complete absence of a part of brain located between the two cerebellar hemispheres.
Signs and symptoms of cerebral palsy with Dandy Walker Syndrome
- Variations in muscle tone, such as being either too stiff or too floppy
- Stiff muscles and exaggerated reflexes (spasticity)
- Stiff muscles with normal reflexes (rigidity)
- Jerky eye movements
- Lack of muscle coordination (ataxia)
- Tremors or involuntary movements
- Slow, writhing movements (athetosis)
- Delays in reaching motor skills milestones, such as pushing up on arms, sitting up alone or crawling
- Favouring one side of the body, such as reaching with only one hand or dragging a leg while crawling
- Difficulty walking, such as walking on toes, a crouched gait, a scissors-like gait with knees crossing or a wide gait
- Excessive drooling or problems with swallowing
- Difficulty with sucking or eating
- Delays in speech development or difficulty speaking
- Difficulty with precise motions, such as picking up a crayon or spoon.
- Blood tests
- CT scan of the head
- Hearing screen
- MRI of head
- Vision testing
Recently, the introduction of stem cells into the field of health sciences has raised the hopes for treatment in neuromuscular and neurological diseases. Stem cells are believed to exist in all tissues in human body and may be totipotent, pluripotent, multipotent depending on tissue type.
Stem cells are mainly classified as Adult stem cells and Embryonic stem cells. They are further classified according to the way they are derived and the source tissues like, Mesenchymal stem cells (MSCs), Haematopoietic stem cells (HSCs) and induced pluripotent stem cells (iPS) cells are the major types of stem cells.
We use MSCs and HSCs that are multipotent, self renewing cells derived from adult tissues that can form a number of cells or tissues that are usually restricted to a particular germ layer. The major advantage of MSCs and HSCs are the ease of harvest and lack of immunoreactivity since they are derived from autologous sources. Autologous stem cells are derived from an individual’s own body, and can be obtained from bone marrow, adipose tissue and peripheral blood. These are processed in tissue culture lab to isolate stem cells which are then used for therapeutic purposes and are then given in the form of doses to the patient.
A cell suspension from immature nervous and haematopoietic tissues is injected into the subarachnoidal space of patient through a spinal puncture (Intrathecally) that can considerably enhance reparative capacities of the nervous tissue and improve the function of damaged brain. This technique is an effective, safe and immunologically proved method of therapy for patients of cerebral palsy with Dandy walker syndrome.
Post stem cell therapy includes occupational therapy, physiotherapy, speech therapy followed by proper diet plan.
Case Study Cerebral Palsy:
A 03 year old baby girl admitted to our hospital for treatment of Cerebral Palsy with Dandy walker syndrome.
Presenting complaints: Unable to walk or stand properly without support, unable to hold neck, twisted extremities, birth history full term normal delivery.
Associated complaints: pathological jaundice 3 days after birth, convulsions since the age of 11 months, last convulsions 15 days before with severe spasm.
Delayed milestones started at the age of 11 months.
Physical examination: Musculoskeletal deformity in hams B/L walks with support, weak reflexes.
Treatment Plan: In cerebral palsy, there is brain tissue damage during pregnancy, delivery or shortly after delivery accompanied by;
- Impaired movement, speaking, hearing, eyesight.
- Lack of co-ordination and mental underdevelopment.
Stem cells provide the most feasible treatment for CP due to their immense regenerative capacity and their ability to differentiate into any type of cell, depending on their surrounding microenvironment. The objective of stem cell therapy is to repair the injured areas.
Here, the stem cell therapy protocol devised was as follows:
- Mesenchymal Stem Cell Transplant:
Bone Marrow & Adipose Tissue derived Stem Cells with Stromal Factor transplanted:
- Intrathecally via lumbar puncture supplemented with,
- Intravenous route.
- Supplementation of deficient vitamins like D3, B12 ,and minerals like zinc, calcium; amino acids like glutathione, arginine and proteins so as to maintain the micro environment needed for stem cell to differentiate and maintain the potency.
- Regular Physiotherapy exercises
Patient showed good improvement symptomatically
Speech improvement (clarity in speech) seen.
Walking only with support of walker, able to climb stairs with minimal help.
Motor reflexes improved
Social- Psychological improvement is observed.
Increase in appetite.
The patient is still under observation and follow up.
Multiple Sclerosis (Disseminated sclerosis or Encephalomyelitis disseminata).
Multiple sclerosis is an inflammatory, autoimmune disease of central nervous system. It destroys myelin, oligodendrocytes and axons affecting the brain and spinal cord. This results in loss of muscle control, vision, balance and sensation. It occurs in both males and females in a ratio of 1:3. A person is high at risk of developing this disease from 13 to 50years of age, which gradually declines thereafter.
Causes of Multiple sclerosis range from genetic mutations, environmental factor and viral infection. The symptoms start between the age of 20 and 40 with a trend of gradual improvement, but may relapse. Early symptoms of MS include blurred or double vision, thinking problems, weakness in arms or legs. The common symptoms are abnormal sensations, bladder problems, fatigue, sexual difficulties, tremors, speech problems, muscle spasms and very rare cases reported breathing problems and seizures.
There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks. Diagnosis of MS is based on ones medical history, Neurological examination, MRI, spinal taps, lumbar punctures.
Conventional methods followed to treat MS:
- The use of the cannabis-derived drug Sativex.
- Low Dose Naltrexone.
Medications used to treat MS while modestly effective can have adverse effects and be poorly tolerated.
Stem Cell Treatment harnesses:
- Aubagio (teriflunomide).
- Avonex (interferon).
- Betaseron (interferon beta-1b).
- Copaxone (glatiramer acetate).
- Gilenya (fingolimod).
- Novantrone (mitoxantrone).
- mitoxantrone (Novatrone).
- mitoxantrone (Cytoxin).
Medications used to treat MS while modestly effective can have adverse effects and be poorly tolerated.
- Relapsing remitting.
- Secondary progressive.
- Primary progressive.
- Progressive relapsing.
An Operational team for treatment include:
- Occupational therapist
- Speech therapist.
Stem cell Therapy for MS:
Present stem cell therapy for MS includes immune-modulation or immunosuppressant along with novel approaches such as interferon, capaxone, or immune suppressants. All act in a non-specific manner blocking immune responses against myelin sheath. Mesenchymal stem cells have immune-regulatory properties that help in regeneration of myelin sheaths of affected neurons. Mesenchymal stem cells and T regulatory cells are embedded inside this tissue. Infusion of adult neural stem cell showed a significant reduction in axonal lesions in multiple locations. Several factors like Brain derived neutrophic factor and Neutrophic-3. Fyn tyrosine kinase is an additional factor that can increase the production of myelin base protein production for remyelination of axons.
Stem cell therapy helps to increase the blood circulation, myelin regeneration, mitochondrial energy production, dietary changes, anti-inflammatory, and antimicrobial and antioxidant factors.
Anti-Aging stem cell therapy helps to retard the degeneration process of the body. Anti-Aging Mechanism: a stem cell’s job is to heal what is damaged. Injury secretes Chemokines. Stem Cells hone in on chemokines. When they arrive they alert regenerative cells to go to work and repair the damage, or grow tissue.
THE PROCEDURE INVOLVES:
Autologous Adipose Stem Cell Enriched Therapy through these five steps namely -Harvest, Separate, Enrich, Activate, Return
Stem cells have the capacity to not only divide to form more stem cells, but also to differentiate into specialized cells to replenish or regenerate dying or damaged tissues. Research shows us that there are millions of “dormant” or inactive stem cells located in our abdominal fat. So the task is to get them out, wake them up, return them to the body where they will get back to work repairing and energizing tissue.
It has been proven that this process does indeed work in reducing the primary marker for aging.. All this within a few weeks after the treatment. Remarkable, yes!